- Monobactam
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Monobactams are β-lactam compounds wherein the β-lactam ring is alone and not fused to another ring (in contrast to most other β-lactams, which have at least two rings). They work only against Gram-negative bacteria.[citation needed]
The only commercially available monobactam antibiotic is aztreonam.
Other examples of monobactams are tigemonam,[1] nocardicin A, and tabtoxin.
Adverse effects to monobactams can include skin rash and occasional abnormal liver functions.
They have no cross-hypersensitivity reactions with penicillin.
References
- ^ Fuchs PC, Jones RN, Barry AL (March 1988). "In vitro antimicrobial activity of tigemonam, a new orally administered monobactam". Antimicrob. Agents Chemother. 32 (3): 346–9. PMC 172173. PMID 3259122. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=3259122.
External links
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