Luca Turin

Luca Turin

Luca Turin (1953 - ) is a biophysicist with a long-standing interest in the sense of smell, the art of perfume, and the fragrance industry.

Vibration theory of olfaction

Since 1996 Turin has been the leading proponent of the vibration theory of olfaction, which proposes that the vibrational spectroscopic properties of molecules can be an important determinant of their associated smells, rather than just the specific "lock and key" ligand binding proposed by the orthodox shape theory of olfaction. Turin suggested that a plausible mechanism for such a molecular spectroscope could be inelastic electron tunneling.

A major prediction of Turin's theory is the isotope effect: that the normal and deuterated versions of a compound should smell different, although they have the same shape. A 2001 study by Haffenden et al showed humans able to distinguish benzaldehyde from its deuterated version [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6R-42G0KG3-B&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ee322cf64e5ae26015b2c5bf70b9f492] [http://www.inference.phy.cam.ac.uk/mackay/smell/] .

However, experimental tests published in Nature Neuroscience in 2004 by Vosshall and Keller failed to support this prediction, with human subjects unable to distinguish acetophenone and its deuterated counterpart [http://www.sciencedaily.com/releases/2004/03/040322080707.htm] . The study was accompanied by an editorial, which considered Vosshall's work to be "refutation of a theory that, while provocative, has almost no credence in scientific circles. The only reason for the authors to do the study, or for "Nature Neuroscience" to publish it, is the extraordinary -- and inappropriate -- degree of publicity that the theory has received from uncritical journalists." [http://www.nature.com/neuro/journal/v7/n4/full/nn0404-315.html] The journal also published a review of "The Emperor of Scent", calling Chandler Burr's book about Turin and his theory "giddy and overwrought." [ Gilbert, Avery. "Nature Neuroscience", p 6, 335 (2003)]

Philosopher of science Miriam Solomon of Temple University, who reviewed Turin's own book in Science [ Solomon, Miriam. "On Smell and Scientific Practice." "Science", pp 763-764, 313 (2006)] , has suggested that "Nature Neuroscience" may have been defensive about the positive publicity surrounding Turin's theory because Nature, the parent journal, famously rejected Turin's original article. [Solomon, Miriam. "Norms of Epistemic Diversity." "Episteme: A Journal of Social Epistemology", pp 23-36, 3.1 (2006) [http://muse.jhu.edu/demo/episteme/v003/3.1solomon.html] ] (Turin's research paper was published instead in "Chemical Senses".) [http://chemse.oxfordjournals.org] Nevertheless, two years after publishing the Vosshall paper and the accompanying editorial, the news website of "Nature" published an article about a study that supported Turin's theory: "A controversial theory of how we smell, which claims that our fine sense of odour depends on quantum mechanics, has been given the thumbs up by a team of physicists." [Citation | last1 = Ball | first1 = Phillip | title = Rogue Theory of Smell Gets a Boost |newspaper = News@Nature | date = 2006-12-07 | url = http://www.nature.com/news/2006/061204/full/news061204-10.html ]

In addition, tests with animals have shown fish and insects able to distinguish isotopes by smell [http://flexitral.com/research/Meloan_1995.pdf] [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=862794] . Biophysical simulations published in Physical Review Letters in 2006 suggest that Turin's proposal is viable from a physics standpoint [http://www.sciencedaily.com/releases/2007/02/070204162541.htm] .

The vibration theory received possible support from a 2004 paper published in the journal Organic Biomolecular Chemistry by Takane and Mitchell, which shows that odor descriptions in the olfaction literature correlate more strongly with vibrational frequency than with molecular shape [http://www.rsc.org/Publishing/Journals/OB/article.asp?doi=B409802A] .

Biography

Turin was born in 1953 in Beirut, Lebanon, to Italian Argentine parents. He lives in London.

Education and employment

Turin earned his Ph.D. in physiology at University College London. From 1982 until 1988, he worked in France as a researcher for the CNRS at the Villefranche Marine Station near Nice. He was then employed at the Pasteur Institute from 1988 until 1990.

After leaving the CNRS, Turin first held a visiting research position at the National Institutes of Health in North Carolina [cite book | author=Burr, Chandler | title=The Emperor of Scent: A Story of Perfume, Obsession, and the Last Mystery of the Senses | publisher=Random House | year=2002 | location=New York | pages=33 | id=ISBN 0-375-50797-3] before moving back to London, where he became a lecturer in biophysics at University College London. In 2001 Turin was hired as CTO of start-up company Flexitral, based in Chantilly, Virginia, to pursue rational odorant design based on his theories.

Role in the case of Henri Korn

Turin's role in reporting a high-profile instance of scientific fraud was reported in 2007 in both Nature and Le Nouvel Observateur.

In 1988, Turin began work at the lab led by neuroscience researcher Henri Korn at the Pasteur Institute. There, Turin and his colleague Nicole Ropert reported to their superiors that they believed some of Korn's research on neurotransmitters was based on fabricated results. [Citation | last = Butler | first = Declan | title = Long-held theory is in danger of losing its nerve | journal = Nature | issue = 449 | pages = 124-125 | date = 2007-09-13 | year = 2007 | url = http://www.nature.com/nature/journal/v449/n7159/full/449124b.html ] After Turin made a formal request that the CNRS investigate the allegations, he was told to find work outside of France; Ropert was also asked to leave. [Citation | last = de Pracontal | first = Michel | title = Fraude à l'Institut Pasteur ? Savants au bord de la crise de nerfs | journal = Le Nouvel Observateur | issue = 2238 | pages = 110 | date = 2007-09-27 | year = 2007 | url = http://hebdo.nouvelobs.com/hebdo/parution/p2238/articles/a355299-savants_au_bord_de_la_crise_de_nerfs.html ] ["Je leur ai expliqué la situation. J'ai dit que le devoir d'un scientifique était d'établir la vérité et que je m'étais trouvé dans un laboratoire dont le directeur agissait comme un faussaire. On m'a répondu que j'avais cinq jours pour me trouver un autre poste, de préférence hors de France !" (Luca Turin, as quoted by Michel de Pracontal in "Le Nouvel Observateur")]

Korn was awarded the prestigious Lounsbery Award in 1992 and became a member of the National Academy of Sciences in the U.S. and the French Academy of Sciences. [Citation | last = de Pracontal | first = Michel | title = Fraude à l'Institut Pasteur ? Savants au bord de la crise de nerfs | journal = Le Nouvel Observateur | issue = 2238 | pages = 108 | date = 2007-09-27 | year = 2007 | url = http://hebdo.nouvelobs.com/hebdo/parution/p2238/articles/a355299-savants_au_bord_de_la_crise_de_nerfs.html ] Then in 2007, re-analysis of Korn's data by in the Journal of Neurophysiology showed serious anomalies that suggested the results were indeed fabricated. [Citation | last = Butler | first = Declan | title = Long-held theory is in danger of losing its nerve | journal = Nature | issue = 449 | pages = 124 | date = 2007-09-13 | year = 2007 | url = http://www.nature.com/nature/journal/v449/n7159/full/449124b.html ]

Publications and media coverage

Turin is the author of the book "The Secret of Scent" (2006), which details the history and science of his theory of olfaction, and an acclaimed critical guide to perfume, "Parfums: Le Guide", with two editions published in French in 1992 and 1994. He is also the subject of the 2002 book "The Emperor of Scent" by Chandler Burr, as well as of the BBC Horizon documentary "A Code in the Nose."

Since 2003, Turin has also written a regular column on perfume, "Duftnote," for "NZZ Folio", the German-language monthly magazine of Swiss newspaper Neue Zürcher Zeitung. The column is also published in English on the magazine's website. [http://www.nzzfolio.ch/www/b019178d-f646-4d0d-a657-023857c7b978/showpages/Suche%20Ergebnis.aspx?q=&v=True&f=1991&t=2008&a=all&st=all&bt=%20alle%20Hefttitel&ct=true&sr=all&ru=0cbe4e7c-f827-45eb-8c84-cf91fbee15da&cc=true&rl=False&ge=False&en=True&ot=False&al=False]

In 2008, Viking Press published "Perfumes: The Guide" by Turin and Tania Sanchez. The book comprises 1,500 critical reviews of individual fragrances, plus introductory essays about the art, science, and history of perfume.

References

*
*

External links

* [http://www.flexitral.com/index.html Flexitral website]
* [http://lucaturin.typepad.com/perfume_notes Perfume Notes (Luca Turin's blog)]


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