Ritodrine

Ritodrine

drugbox
IUPAC_name=4- [2- [2-hydroxy-2-(4-hydroxyphenyl)-1-
methyl-ethyl] aminoethyl] phenol


CAS_number=26652-09-5
ATC_prefix=G02
ATC_suffix=CA01
ATC_supplemental=
PubChem=33572
DrugBank=APRD00541
C=17|H=21|N=1|O=3
molecular_weight=287.354 g/mol
bioavailability=
protein_bound=~56%
metabolism=
elimination_half-life=1.7-2.6 hours
excretion=
pregnancy_AU=
pregnancy_US=
pregnancy_category=
legal_AU=
legal_UK=
legal_US=
legal_status=
routes_of_administration=Oral, parenteral

Ritodrine hydrochloride (trade name Yutopar) is a tocolytic drug, used to stop premature labor.cite journal |author=Li X, Zhang Y, Shi Z |title=Ritodrine in the treatment of preterm labour: a meta-analysis |journal=The Indian journal of medical research |volume=121 |issue=2 |pages=120–7 |year=2005 |month=February |pmid=15756046 |doi= |url=http://www.icmr.nic.in/ijmr/2005/February/0207.pdf] It is available in oral tablets or as an injection.

Mechanism

Ritodrine is a Beta-2 adrenergic receptor agonist - a class of medication used for smooth muscle relaxation (other types are used in asthma or other pulmonary diseases)

ide effects and potential contraindications

Most side effects of beta-2 agonists result from their concurrent beta-1 activity, and include increase in heart rate, rise in systolic pressure, decrease in diastolic pressure, chest pain secondary to MI, and arrhythmia. Beta agonists may also cause fluid retention secondary to decrease in water clearance, which when added to the tachycardia and increased myocardial work, may result in cardiac failure. In addition, they increase gluconeogenesis in the liver and muscle resulting in hyperglycemia, which increases insulin requirements in diabetic patients. The passage of beta-agonists through the placenta does occur and may be responsible for fetal tachycardia, as well as hypoglycemia or hyperglycemia at birth.

Patients with Type 2 Diabetes, high blood pressure or migraines should bring this to their doctor's attention before receiving care.

It has also been associated with post partum haemorrhage.

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • ritodrine — noun A tocolytic drug, used to stop premature labour …   Wiktionary

  • ritodrine — A sympathomimetic agent with β2 adrenergic stimulant actions, used as a uterine relaxant. * * * rit·o·drine rit ə .drēn, drən n a drug administered intravenously in the form of its hydrochloride C17H21NO3·HCl as a smooth muscle relaxant esp. to… …   Medical dictionary

  • ritodrine — n.; see sympathomimetic …   The new mediacal dictionary

  • ritodrine — …   Useful english dictionary

  • ritodrine hydrochloride — rit·o·drine hy·dro·chlor·ide (ritґo drēn) [USP] a beta2 adrenergic agent used as a smooth muscle (uterine muscle) relaxant to delay uncomplicated premature labor; administered orally and intravenously …   Medical dictionary

  • Oxytocin — Systematic (IUPAC) name 1 ({(4R,7S,10S …   Wikipedia

  • Adrenergic receptor — Epinephrine Norepinephrine The adrenergic receptors (or adrenoceptors) are a class of met …   Wikipedia

  • Salbutamol — (S) Salbutamol Systematic (IUPAC) name …   Wikipedia

  • Nifedipine — Systematic (IUPAC) name 3,5 dimethyl 2,6 dim …   Wikipedia

  • Tocolytic — Tocolytics (also called anti contraction medications or labour repressants) are medications used to suppress premature labor (from the Greek tokos, childbirth, and lytic, capable of dissolving). They are given when delivery would result in… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”